Examining Genetic Variants with Liquid Biopsy and Tumor Samples

Ocean Ridge Biosciences offers cost-effective ultra-deep sequencing of targeted genes to analyze genetic variants in solid tumors, cell-free DNA (cfDNA), and genomic DNA. Utilizing highly parallel multiplex next-generation sequencing of PCR amplicons, ORB's oncogene panel, or oncopanel, sequencing and analysis enables investigation of cancer-related genes or genomic regions, such as tumor suppressor genes such as BRCA1 or TP53, and oncogenes that can turn healthy cells into cancer cells. The focused nature of oncopanels can reduce costs and increase the speed of genomic studies because only a limited set of genes are interrogated. Additional benefits include advanced detection of low-frequency variants with deeper sequencing options and production of more manageable datasets than traditional whole genome sequencing studies.

Sample Types and Sample Submission Instructions

Common Oncology Areas Utilizing Oncopanels

ORB’s Oncogene Analysis Service

ORB offers analysis of numerous genetic variant types using oncopanels from industry leading manufacturers where starting materials are optimized for low-input and degraded samples, e.g. FFPE tissues. Many panels require as little as 10 ng of gDNA per sample, please see Table I for a list of available panels and associated variant types. Contact us to determine which panel would be most appropriate for your cancer investigation.

Table I. Oncopanels available for analysis using ORB's oncogene analysis service.