Genomic & Biopharma News

Exosomal HSP60 has great potential for clinical applications as a liquid biopsy
Cell-to-cell communication is imperative for life and it is mediated by sending and receiving information via the secretion and subsequent receptor-mediated detection of biological molecules. Exosomes (EXs) secreted from cells to the extracellular environment play an important role in intercellular communication in normal and pathological conditions. Areas covered: New evidence indicates that tumor cells-derived EXs ...
Exosome RNA Research & Industry News, 2017-07-20 11:39:06

RNA-Seq uncovers super cell that ‘locks up’ Ebola
Scars on the eyes of an Ebola survivor have led researchers to a ‘super cell’ that may have the potential to help contain the virus in future outbreaks. A paper published in Translational Vision Science & Technology today describes how retinal pigment epithelial cells may act as a ‘reservoir’ for Ebola and keep it from spreading. The ...
Transcriptome Research & Industry News, 2017-07-20 11:23:24

Risk of caesarean reduced by healthy diet and physical activity during pregnancy, study finds
A new study published by The BMJ, on 19th July 2017, states that encouraging healthy diets and physical activity during pregnancy can restrict excess gain of weight as well as reduce the chance of having caesarean sections.
News Medical Life Sciences, 2017-07-20 11:02:00

Theravance COPD drug clears safety study, setting up NDA
Theravance Biopharma and Mylan are still on course to file for approval of their nebulized chronic obstructive pulmonary disease (COPD) therapy in the fourth quarter after posting 12-month safety data. The trial suggests revefenacin has a tolerable safety profile comparable to that of Boehringer Ingelheim’s bronchodilator Spiriva.
Fierce Biotech, 2017-07-20 10:27:39

These preventive measures might help delay dementia or cognitive decline
In a landmark report, scientists have endorsed three strategies for preventing dementia and cognitive decline associated with normal aging — being physically active, engaging in cognitive training and controlling high blood pressure.
News Medical Life Sciences, 2017-07-20 10:22:00

EU approves LEO Pharma’s psoriasis biologic
A new treatment option has been approved in the European Union for patients with psoriasis, paving the way for access to a novel approach for those with moderate-to-severe forms of the disease who are candidates for systemic therapy.
PharmaTimes, 2017-07-20 09:23:18

Novartis, Sanofi-backed NeuroVia closes $14M series A for X-ALD work
Sanofi Genzyme's and Novartis’ venture arms have backed NeuroVia, an upstart that wants to help treat the rare CNS disorder X-linked adrenoleukodystrophy.
Fierce Biotech, 2017-07-20 09:22:43

lncRNAs and MYC – An Intricate Relationship
Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression networks, acting either at the transcriptional level, by influencing histone modifications, or at the post-transcriptional level, by controlling mRNA stability and translation. Among the gene expression networks known to influence the process of oncogenic transformation, the one controlled by the proto-oncogene MYC is ...
lncRNA Research and Industry News, 2017-07-20 09:00:31

Novel small RNA spike-in oligonucleotides enable absolute normalization of small RNA-Seq data
Normalization of high-throughput small RNA sequencing (sRNA-Seq) data is required to compare sRNA levels across different samples. Commonly used relative normalization approaches can cause erroneous conclusions due to fluctuating small RNA populations between tissues. Researchers from the Austrian Academy of Sciences developed a set of sRNA spike-in oligonucleotides (sRNA spike-ins) that enable absolute normalization of ...
Transcriptome Research & Industry News, 2017-07-20 09:00:02