Genomic & Biopharma News

Ardelyx reports positive phase 3 data, but shares fall hard premarket
Ardelyx says it has hit its primary endpoint and most of its secondary endpoints in a late-stage test of its IBS (with constipation) candidate tenapanor, but investors were spooked as its shares spiraled downward premarket.
Fierce Biotech, 2017-05-12 12:45:53

Impulse Dynamics bags $45M for chronic heart failure device
Impulse Dynamics raised $45 million in equity for its device that treats chronic heart failure by delivering electrical pulses to boost the heart’s ability to contract.
Fierce Biotech, 2017-05-12 12:42:53

Study findings may help shed light on cause of systemic sclerosis
Americans and Norwegians with systemic sclerosis had higher levels of bacteria that can cause inflammation and lower levels of bacteria that are believed to protect against inflammation compared with healthy people, according to a new study by researchers from UCLA and Oslo University.
News Medical Life Sciences, 2017-05-12 12:30:24

Protein sequestration as a normal function of long noncoding RNAs
An emerging class of long noncoding RNAs (lncRNAs) function as decoy molecules that bind and sequester proteins thereby inhibiting their normal functions. Titration of proteins by lncRNAs has wide-ranging effects affecting nearly all steps in gene expression. While decoy lncRNAs play a role in normal physiology, RNAs expressed from alleles containing nucleotide repeat expansions can ...
lncRNA Research and Industry News, 2017-05-12 12:14:47

Lilly’s galcanezumab meets goals in phase 3 migraine trials, tucking it in behind Amgen, Novartis in race for market
Eli Lilly has posted positive data from three phase 3 trials of galcanezumab in migraine patients. But while the data show galcanezumab cuts the number of days patients suffer from migraines, they fell short of delivering a knockout blow to Amgen and Novartis’ rival drug erenumab.
Fierce Biotech, 2017-05-12 12:13:04

Exosomes as potential alternatives to stem cell therapy
The stem cell-based therapies for intervertebral disc degeneration have been widely studied. However, the mechanisms of mesenchymal stem cells interacting with intervertebral disc cells, such as nucleus pulposus cells (NPCs), remain unknown. Exosomes as a vital paracrine mechanism in cell-cell communication have been highly focused on. Researchers from the Third Military Medical University set out to ...
Exosome RNA Research & Industry News, 2017-05-12 12:04:30

Single Cell RNA Sequencing Technologies – The Advantages of Being Single amongst Singles
Monday –  22 May 2017 12:00 pm – 1:00 pm Walter and Eliza Hall Institute of Medical Research – University of Melbourne In the past two decades high throughput DNA sequencing technologies have emerged and have rapidly become available to labs across the world. This technological breakthrough has given rise to many different applications that ...
Transcriptome Research & Industry News, 2017-05-12 11:53:15

Immunoreceptor promotes tumor growth in mouse models of liver cancer driven by inflammation
Boosting a part of the immune system known to have anti-tumor properties may actually help tumors grow in cancers linked to chronic inflammation.
News Medical Life Sciences, 2017-05-12 11:39:06

Analyzing single-cell RNA data in pre-malignant tumors
RNA sequencing is basically the isolation of RNA from cells and the use of reverse transcriptase to turn the RNA into DNA. You can then use your standard DNA sequencing technologies to quantify the cDNA that you obtained from the reverse transcription reaction.
News Medical Life Sciences, 2017-05-12 11:34:00