Genomic & Biopharma News

Acorda Parkinson's trial hits endpoint, teeing up FDA filing
Acorda Parkinson's trial hits endpoint, teeing up FDA filing nick.paul.taylor Thu, 02/09/2017 - 08:39
Fierce Biotech, 2017-02-09 13:39:25

Which regression model is right for your RNA-Seq analysis?
Next generation sequencing provides a count of RNA molecules in the form of short reads, yielding discrete, often highly non-normally distributed gene expression measurements. Although Negative Binomial (NB) regression has been generally accepted in the analysis of RNA sequencing (RNA-Seq) data, its appropriateness has not been exhaustively evaluated. Boston University researchers explore logistic regression as ...
Transcriptome Research & Industry News, 2017-02-09 13:30:38

Male contraceptive proves effective at preventing pregnancy amongst monkeys
Treating male monkeys with the contraceptive Vasalgel has proved effective at preventing conception amongst rhesus monkeys, reports the California National Primate Research Center. The report is based on findings from a study that involved sixteen rhesus monkeys that were treated with the contraceptive...
News Medical Life Sciences, 2017-02-09 13:21:53

Cancer drugmaker Tesaro weighs its options as wannabe buyers come running
Cancer drugmaker Tesaro weighs its options as wannabe buyers come running chelfand Thu, 02/09/2017 - 08:21
Fierce Pharma, 2017-02-09 13:21:05

The Feasibility of Using Mutation Detection in ctDNA to Assess Tumor Dynamics
For many decades it has been known that tumor DNA is shed into the blood. As a consequence of technological limitations, researchers were unable to comprehensively characterize circulating DNA. The advent of ultrasensitive and highly specific molecular assays has provided a comprehensive profile of the molecular characteristics and dynamics of circulating DNA in healthy subjects ...
Exosome RNA Research & Industry News, 2017-02-09 13:20:40

A “coding” long non-coding RNA
from Genetic Engineering News Although long noncoding RNAs (lncRNAs) are by definition noncoding, they are known to encode disproportionately short molecules—mere polypeptides, not proteins. Whether these polypeptides matter very much is another question. They could represent nothing more than transcriptional noise, or they could be—as a new study suggests—functionally relevant. In the new study, scientists ...
lncRNA Research and Industry News, 2017-02-09 12:35:38

Pfizer to close Australia plant, whack 89 jobs
Pfizer to close Australia plant, whack 89 jobs epalmer Thu, 02/09/2017 - 07:29
Fierce Pharma, 2017-02-09 12:29:35

Exosome isolation using ultracentrifugation
In the outpatient clinic and in the laboratory our current research studies aim at understanding the mechanisms of release and clearance and the biological functions of exosomes and membrane particles in the plasma of individuals who develop emphysema, a form of chronic obstructive pulmonary disease characterized by enlargement of airspaces and loss of alveoli.
News Medical Life Sciences, 2017-02-09 12:27:00

The role of pancreatic cancer-derived exosomes in cancer progress and their potential application as biomarkers
Pancreatic cancer is one of the most deadly cancers, with dismal prognosis due to its poor early detection rate and high metastatic rate. Thus, elucidation of the molecular mechanisms accounting for its metastasis and discovery of competent biomarkers is required. Exosomes are multivesicular body-derived small extracellular vesicles released by various cell types that serve as ...
Exosome RNA Research & Industry News, 2017-02-09 12:23:58