Genomic & Biopharma News

Study reveals impact of TP53 gene mutations on MDS severity
Considered the "guardian of the genome," TP53 is the most commonly mutated gene in cancer. TP53's normal function is to detect DNA damage and prevent cells from passing this damage on to daughter cells.
News Medical Life Sciences, 2020-08-04 01:06:19

ORB Employees Participate in 2019 Martin Luther King Day Event
ORB employees get a rare break from the lab on January 21, 2019. A group of Ocean Ridge Biosciences employees stepped out of the lab on a beautiful South Florida winter day to take part in an event honoring Martin Luther King. We got our hands dirty planting some flowers and shrubs at a local park in Deerfield Beach.
ORB Company News, 2019-01-22 23:24:59

Chlamydiae need a lot of glutamine to multiply in human cells
If chlamydiae want to multiply in a human cell, the first thing they need is a lot of glutamine. Würzburg researchers have clarified how the pathogenic bacteria obtain this substance.
News Medical Life Sciences, 2020-08-04 00:50:02

Membrane protein regulates epigenetic plasticity by mediating iron endocytosis
CNRS researchers at the Institut Curie have recently shown that cancer cells use a membrane protein that has been known for several decades to internalise iron.
News Medical Life Sciences, 2020-08-04 00:40:12

Darolutamide shows indication of considerable added benefit in prostate cancer
Up to now, adult men with non-metastatic castration-resistant prostate cancer (nmCRPC) at high risk of developing metastatic disease usually continued their conventional androgen deprivation therapy (ADT) while the cancer was observed for the occurrence of metastases (so-called watchful waiting).
News Medical Life Sciences, 2020-08-04 00:23:55

Penn researchers identify genetic driver of Charcot-Marie-Tooth disease
Inherited mutations in a gene that keeps nerve cells intact was shown, for the first time, to be a driver of a neuropathy known as Charcot-Marie-Tooth (CMT) disease.
News Medical Life Sciences, 2020-08-04 00:20:17

Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma

Nature, 2020-08-04 00:00:00

PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins

Nature, 2020-08-04 00:00:00

Harnessing the microbiome potential
Spring is underway in parts of the US, and while Florida by no means undergoes the dramatic reappearance of foliage or colorful clumps of daffodils and azaleas, the southern part of the sunshine state experiences its share of spring renewals.  For instance, recently a brood of Muscovy duck (Cairina moschata) hatchlings appeared near Ocean Ridge Biosciences' laboratory.
ORB Company Blog, 2017-03-31 21:41:45

Extensive study of SARS-CoV-2 sequencing reveals six strains of the virus
The virus causing the COVID-19 pandemic, SARS-CoV-2, presents at least six strains. Despite its mutations, the virus shows little variability, and this is good news for the researchers working on a viable vaccine.
News Medical Life Sciences, 2020-08-03 23:58:56

Study shows how G406R single point mutation of the Cav1.2 channel confers autism
Autism spectrum disorder (ASD) is a heterogeneous disorder initiated early in development and characterized by abnormal social communication. Accumulating evidence supports the idea that specific mutations affect regulatory proteins that control arrays of cellular pathways.
News Medical Life Sciences, 2020-08-03 23:52:18