ORB provides investigative research services to characterize genomic, metatranscriptomic, epigenomic, and proteomic signatures from a wide variety of biological samples including tissue biopsies, cells, stool, and many biofluids as shown in Tables I and II below; corresponding starting input requirements can be downloaded here. Visit the protocols and methods page to download ORB’s reccommended procedures for sample isolation and handling. Prior to shipping, complete a sample submission checklist appropriate for your sample type and selected analysis application. If you do not see your sample type, contact us to discuss processing options; ORB’s R&D scientists can develop a process for isolation of nucleic acids and/ or handling of your unique samples. Please note, ORB’s minimum sample requirements are frequently lowered to conserve limited starting materials. Check out our current limits!

Table I. RNA profiling - accepted sample types.

Sample Type Accepted Sample Types
  Sequencing—
small RNA
Sequencing—
long RNA
Microarray—
mRNA
Microarray—
small RNA1
Frozen or RNAlater tissues O, A
Cultured cell lysates O, A
Buffy coat or PBMCs O, A
LCM cells  
Immuno-precipitated RNA    
OCT-tissue blocks O, A
HITS-CLIP or PAR-CLIP RNA    
Stool samples      
Exosomal long RNA      
Exosomal small RNA     O
FFPE   O
Whole Blood   O, A
Serum, plasma, lymph, lavage,
tears, milk, urine, saliva, semen,
CSF. Synovial, acites, and amniotic fluids.
    O
Degraded RNA   O

1, O - ORB’s proprietary miRBase version 19 microRNA microarray, A - Affymetrix microRNA 4.0 microarray

Table II. Additional assays—sample types accepted.

Sample Type Accepted Sample Types
  Immunoassays Real-Time qPCR Methylation Oncopanels
Frozen or RNAlater tissues frozen only  
Cultured cell lysates    
Buffy coat or PBMCs    
LCM cells      
Immuno-precipitated RNA      
OCT-tissue blocks    
HITS-CLIP or PAR-CLIP RNA      
Exosomal long RNA      
Exosomal small RNA      
FFPE   Coming soon!   Coming soon!
Whole Blood    
Serum, plasma, lymph, lavage,
tears, milk, urine, saliva, semen,
and cerebrospinal, synovial,
acites, and amniotic fluids
 
Genomic DNA      
Cell-free DNA